Platelets are a key component of blood that plays an essential role in wound healing. They are a reservoir of growth factors and cytokines that are involved in the process of tissue maturation and healing. Platelet rich fibrin (PRF), a second generation platelet concentrate, is an autologous preparation of blood. It contains large quantity of platelets and cytokines. PRF presents a novel therapeutic conception with no biochemical processing of blood. The crux of PRF synthesis lies in the attempt to accumulate platelets and cytokines in a fibrin clot. It is a simple and cost effective method at attempting enhanced healing and recovery of tissues.