Background: Hypertensive disorders of pregnancy are one of the most common medical disorders in pregnancy with a 5-15% incidence rate in India. These are multisystem disorders and lead to a lot of cellular death. LDH is an intracellular enzyme and its level is increased in these women due to cellular death. Hyperuricemia is found to be one of the earliest laboratory manifestations of preeclampsia. It is likely to be resulted from reduced UA clearance from reduced glomerular filtration rate (GFR) and reduced tubular secretion. Its increased levels suggest serious impending damage to kidney functions. So, serum LDH levels and Uric acid can be used to assess the extent of cellular death and thereby the severity of disease. Objectives: This study was done to compare serum levels of lactate dehydrogenase (LDH) and uric acid (UA) among women with HDP and normal pregnant women and its significance as prognostic markers in Hypertensive disorders of pregnancy. Materials and methods: This study was a comparative observational study conducted among 140 Antenatal women in third trimester attending Antenatal OPD/Labour ward at SMS Medical College during January to December 2017. Serum levels of LDH and UA were measured using commercially available kits. Statistical analysis was done. Observation and results: In our study, Serum levels of LDH and UA were significantly increased in women with HDP compared with controls. LDH & UA were significantly high in preeclampsia & eclampsia group. Their levels significantly positively correlated with systolic and diastolic BP. Conclusion: Serum LDH and UA levels gradually increase as the disease severity increases. Regular monitoring of their serum levels in women with HDP may give a clue of disease severity and associated organ damage.