Purpose: To compare the outcome of sublingual misoprostol versus intramuscular oxytocin in the active management of third stage of labour.

Methods: This randomized control study included 332 cases who fulfilling selection criteria, the study cases comprised of those women in the third stage of labour after vaginal delivery. Patients were randomly allocated into two groups, group A (166 cases) receive 400μg sublingual Misoprostol tablet and group B (166 cases) receive 10 IU intramuscular oxytocin after delivery of baby, before cord clamping. The main outcome measures estimation of amount of blood loss in 1st one hour of labour, next 23 hours and total blood loss upto 24 hours.

Results: There Mean blood loss during third stage of labour.was not statistically significant in groupA, recieve 400 μg sublingual Misoprostol tablet and groupB, receive 10 IU intramuscular oxytocin after delivery (p>.05).

Conclusion: The sublingual misoprostol 400 mcg appers to be as effective as intramuscular oxytocin 10 IU in the active management of third stage of labour.