Abstract

Poly-N-Vinyl Pyrrolidone (PVP) with molecular formula (C6H9NO) x, of molecular weight 40,000 is a water soluble polymer, is a highly biocompatible polyactamide homopolymer. PVP is taken as an important component is firstly converted into it oxime derivative. PVP is treated with hydroxylamine hydrochloride (NH2OH.HCl) in alkaline medium to facilitate smooth reaction. Spectroscopic characterization of the PVP-Oxime molecule is carried by Fourier Transmission IR Spectra, 1H NMR Spectra, UV-VIS Spectrophotometer. The IR vibration frequencies of PVPOxime show the presence of side chains as poly vinyl chain. 1H NMR Spectra infers the presence of oxime group in the molecule. At 0.001% concentration of PVP-Oxime absorbance of UV-Vis spectra is studied. Physico-chemical characterization of the PVP-Oxime molecule is studied by sophisticated Analytical instrument Survismeter. It includes Viscosity, Surface tension, Friccohesity, interaction between the molecules, volumetric interaction in bulk and in thin films. The 0.001%, 0.0005%, 0.00025%, 0.000125%, 0.0000625% samples of different concentration of PVP-Oxime in aqueous media are studied for adhesive, cohesive, frictional forces, Wetting and De-wetting effects. The supramolecule can be extensively applied as an adsorbent surfaces for many bio-physicochemical phenomena. The surface morphology of the Poly-N-Vinyl Pyrrolidone and its Oxime molecules are studied by Scanning Electron Microscopy (SEM) techniques. The porosity and the nanostructure surface properties of the molecule can be studied. Thus the  physico-chemical and structural Characterization of the PVP and PVP-Oxime nano particles reveals us the Physical, Chemical and biological activities of the molecule making it more applicable in broad areas of medicinal chemistry, Bio-physical Engineering, Drug chemistry as nano bio-chips, biosensors, drug loading and drug delivery systems, etc.