Abstract
Background: Laryngoscopy and tracheal intubation are invariably associated with certain stress responses due to the sympatho-adrenal stimulation. These cardiovascular and neurohumoral alterations may directly affect the physiology and increase the risk. Various drugs have been tried but no one drug has been considered ideal for blunting this pressorresponse.
Objectives: This comparative study was planned to evaluate and compare the efficacy of intravenous magnesium sulphate (30 mg/kg) along with lidocaine 2% versus intravenous fentanyl with lidocaine 2%,in attenuating the presser response to laryngoscopy and tracheal Intubation.
Methods and Materials: One hundred patients were randomised to receive either magnesium sulphate 30 mg/kg diluted in 100 ml saline (Group M) along with 2% lidocaine or Intravenous fentanyl 2mcg/kg along with lidocaine 2%.1 (Group F) 10 min before induction of anaesthesia . After laryngoscopy and intubation were performed, heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded pre-drug, after drug, at intubation, at intervals of 1min , 5 min, and 10 min post intubation.
Statistical analysis used: The collected data was analysed with IBM.SPSS statistics software 23.0 Version. To describe about the data, descriptive statistics frequency analysis, percentage analysis was used for categorical variables, and for continuous variables the mean and SD was used. To find the significant difference between the bivariate samples in Independent groups the unpaired sample t-test was used. To find the significance in categorical data, Chi-Square test was used. In both the above statistical tools the probability value of 0.05 was considered as significant.
Results: There was a significant statistical difference in both the groups in terms of heart rate and blood pressure at one and five minutes after intubation.
Conclusion: Prophylactic administration of combination of magnesium sulphate and 2% lidocaine was found to be effective in attenuating hemodynamic responses to the stress effect of laryngoscopy and intubation as compared to intravenous Fentanyl.