Introduction: A central line-associated bloodstream infection (CLABSI) is quite common in an intensive care unit (ICU) and results in a prolonged stay with multiple complications. This study tried to reveal existing knowledge deficits among the newly recruited nursing staff about central venous line (CVL) care. This study also highlights the usefulness of "flipped classroom’ and "interactive practical classes" techniques in re-educating nursing staff about CVL basics and management and their impact on nursing staff performance in managing CVL.  
Methods: This is a cohort study conducted at a tertiary care centre from August 2021–January 2022. A total of 20 newly recruited nursing staff (with 1 to 3 years of nursing experience) underwent a pre-test comprising 25 questions about central venous line (CVL) basics and management. All the 20 newly recruited nursing staff had at least 6 months of prior experience of working in an ICU at different hospitals. This was followed by an intervention in the form of "flipped classroom’ and "interactive practical classes’ with individualized attention. A post-test was conducted following these classes to assess the knowledge gained. A total score of pre-test and post-test activities was calculated for each nurse.
Results: The mean age of the participants was 24.6 years. All the 20 participants had exposure to the CLABSI prevention guidelines during their initial days of training at their respective nursing colleges. 20 participants scored a mean of 21.4 2.4 during the pre-test. A post-test mean score increased to 23.1 ± 1.0 in Section-A. Similarly, 20 participants scored a mean of 8.4 ± 0.94 during the pre-test. A post-test mean score increased to 9.4 ± 0.94 in Section-B.
Conclusion: Our study showed that with the help of newer learning techniques, the overall knowledge and management skills in managing CVL of newly recruited nurses increased significantly.

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and acquired immunodeficiency syndrome (AIDS) (Douek et al., 2009). AIDS is a condition in humans in which progressive failure of immune system allows life-threatening opportunistic infections and cancers to thrive. In the present study carried out on 942 patients with various sexually transmitted diseases 65 patients were found to be seropositive for HIV. Out of these 42 were males (64.61%) while 23 were females (35.38%) which are lower than Burzin et al. (2006) from Ahmedabad reported 77.51% males and 22.49% females found seropositive for HIV. This might be due to less no. of patients in our study. Large number of cases in males in comparison to females is explained from the fact that in females the social stigma and discrimination prevents the women to seek help of STD clinic facility, which in turn contribute higher cases in males. Hence, our study support the males are affected than the opposite sex. Among 65 HIV patients, herpes Progenitalis is the commonest STD with 28 cases (43.07%), followed by Syphilis (18.45%), Mixed VDs (12.3%), Molluscum contagiosum (7.69%), Gonorrhoea (6.15%), Chancroid (4.61%), Condyloma acuminate (3.07%), Granuloma Inguinale (1.53%), Lymphogranuloma venereum (1.53%) and Nongonococcal urethritis (1.53%) indicating that HIV is co-supplemented with STDs and such STD patients are high risk of HIV Seropositivity.