Multiple events of building collapse from heavy rains and rising temperature are recorded each year and predicted to rise in the future. Therefore, this study examined the influence of meteorological parameters such as rainfall and temperature on building collapse in the Niger Delta region. The ex post facto research was adopted in this study.Meteorological data (rainfall and temperature) were sourced from the archives of Nigerian Meteorological Agency (NiMet) for a period of 41 years whereas information on building collapse was obtained from the records of National Emergency Management Agency (NEMA). Descriptive statistics, statistical diagrams and tables were used to present the data.  A kendall tau-b correlation was performed to determine the relationship between time (years) and the meteorological parameters (rainfall and temperature) across the sampled locations in the Niger Delta region and also to point out the trends in the data sets. The results show a positive correlation between time (years) and rainfall in Akure (tb=.254, p= .018), Benin (tb=.082, p= .795), Warri (tb=.028, p= .795), Yenagoa (tb=.119, p= .269), Port Harcourt (tb=.112, p= .298), Uyo (tb=.030, p= .778), Calabar (tb=.030, p= .778), Owerri (tb=.121, p=.260), and Umuahia (tb=.200, p= .062). These correlations were only significant in Akure at p<0.05 implying an increase in rainfall trend and an inverse trend in other locations in the region.Also, a  positive correlation between time (years) and temperature was revealed in Akure (tb=.322, p= .003), Benin (tb=.490, p= .000), Warri (tb=.553, p= .000), Yenagoa (tb=.585, p= .000), Port Harcourt (tb=.596, p= .000), Uyo (tb=.665, p= .000), Calabar (tb=.665, p= .000), Owerri (tb=.582, p= .000), and Umuahia (tb=.610, p= .000) and they were all significant at p<0.05implying that temperature rises concomitantly as the years progresses in the region. Consequently, mandatory design of building plans capturing trees planting and green landscape, use of climate resilient materials in building construction, enactment and enforcement of climate policies in relation to building health, stability and safety were recommended.

Introduction: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine system conditions affecting women of reproductive age is also known as hyper -androgenic anovulation (HA) or Stein–Leventhal syndrome. This chronic and heterogeneous disorder manifests itself as menstrual dysfunction, infertility, hirsutism, acne, and obesity.
Purpose: This study was done to assess the prevalence and the knowledge regarding polycystic ovary syndrome amongst the student nurses.
Methodology: The research approach was quantitative.
Design: Pre experiment one group pre-test post-test research design was adopted for the present study. Pretest knowledge was assessed and after that structured teaching program (STP) was administered, then the posttest knowledge was assessed
Sample: 134 student nurses who were pursuing Diploma in General Nursing Midwifery student nurses were selected by convenient sampling technique.Structured questionnaire was developed to collect data and it was shared with the students in form of google form through a link.data analysis was by descriptive and inferential statistics.
Result:The study findings revealed that the prevalence of polycystic ovary disease among the student nurseswas 6.7% and the findings related to effectiveness of structured teaching program were out of 134, in pre-test 37(28%) is having good knowledge, 50 (37%) is having average knowledge and 47(35%) is having poor knowledge whereas in post-test out of 134, 103(77%) is having good knowledge, 25(19%) is having average knowledge and 6(4.5%) is having poor knowledge.

Since Fritz Vogtle first introduced the dendrimer in 1978, the field has grown a lot, covering everything from how they are made to their many uses. Because of their special features, like their tiny size, multiple functional surfaces, high branching, and hollow centers, dendrimers are naturally ideal for various applications. They are especially good for delivering drugs Compared to linear polymers, dendrimers have a more defined size, shape, molecular weight, and uniformity. They have a tree-like structure with a central core, branches, and terminal groups. The active ingredients can be attached to the surface of the dendrimer either physically or chemically, or they can be placed inside the molecule. Dendrimers are nanoscale, radially symmetrical molecules with a consistent and uniform structure. They have a typical symmetrical core, an inner shell, and an outer shell. The structure of the dendrimer plays a big role in how drugs are released. They grow outward from the core-shell structure, which then interacts with monomers. These molecules are very compatible with biological systems. They have a highly branched structure and a well-defined spherical shape. These unique properties make dendrimers useful in many areas, including medicine and biomedical applications. Dendrimer-based nano formulations help improve the solubility of poorly soluble substances, allowing medications to reach target tissues more effectively, increasing bioavailability, and enabling controlled drug release.

Cubosomes are square or rounded particles that have an internal cubic structure. They are thermodynamically stable and made up of honeycomb-like shapes that create two separate water-filled areas inside. These are nanoparticles that naturally form by creating a large surface area and channels.
The correct mix of water and certain surfactants was used to make liquid crystalline particles with a special structure that gives them unique properties.
A real concern is that the bicontinuous cubic liquid crystalline phase has a special structure at the nanometer level, it is clear, and it is very thick. A twisted lipid layer separates two continuous but not connected water areas. The term bicontinuous describes this separation. Cubosomes are usually made by mixing a polar lipid or surfactant to form a cubic phase and then breaking it into smaller particles.
Because of their unique bicontinuous cubic structure, cubosomes are great for delivering drugs through the skin. These particles offer several benefits, including the ability to carry a large amount of medication, they are stable, and can hold both water-soluble and fat-soluble drugs, making them useful for many different types of treatments.

Molecular docking is an essential computational tool widely used in modern pharmaceutical research. Although originally applied to drug discovery, docking has expanded into formulation development, excipient compatibility assessment, nanoparticle design, liposomal encapsulation, and herbal standardisation. Docking predicts the binding mode, stability, and interaction forces between a ligand and its biological or formulation-related target. These predictions reduce experimental workload, accelerate decision-making, and provide mechanistic justification for formulation choices.
This review summarises the principles of docking, conformational sampling, scoring functions, and validation approaches. Applications in drug discovery include target identification, virtual screening, lead optimisation, repurposing, and ADME prediction. In formulation science, docking plays a major role in drug–excipient compatibility, cyclodextrin inclusion complexes, lipid and polymer-based nanocarriers, transdermal and oral drug delivery systems, and herbal/nutraceutical formulations.
Ten detailed case studies from recent research demonstrate how docking supports nail lacquers, liposomes, nanoparticles, paediatric formulations, antiviral herbal mixtures, and anti-inflammatory phytosomes. Challenges such as scoring errors, rigid receptor models, solvent issues, entropy, and computational limitations are discussed. Future trends include AI-driven docking, machine learning scoring functions, MD integration, quantum approaches, and personalised medicine. Overall, docking enhances scientific understanding, supports regulatory justification, and improves the design of safe and effective pharmaceutical products.

The study investigates the buying, consumption, and disposal behavior of sarees of Sri Lankan consumers, with the ultimate aim of proposing sustainable interventions to extend its lifespan and promote the responsible usage. The study further explore the  average life time  of a daily wear saree and investigate the determinants of its durability  and  discover novel approaches in reviving old sarees through giving new look to it. The methodology comprises of questionnaire surveys, interviews, and practice based design experiments. Different age groups and socio-economic levels were involved in questionnaire surveys and interviews in order to get a holistic perspective on buying, consumption, and disposal practice. The study contributes to the growing area of sustainable fashion by offering culturally sensitive and practical solutions to promote longevity of sarees, reduce textile wastage, and foster renewed respect for traditional dress in modern environments.

Objectives: One key area of research in drug delivery is transdermal drug delivery systems (TDDS), which have distinct benefits compared to oral and injection methods. Scientists are concentrating on using microneedles to get past the outer layer of skin, known as the stratum corneum. Microneedles can deliver medication into the epidermis without harming nerve endings. This review highlights recent progress in microneedle technology to help young scientists and encourage further research in this field.
Key Findings: Microneedles are created using a microelectromechanical system that incorporates materials like silicon, metals, polymers, or polysaccharides. Solid coated microneedles can penetrate the top layer of skin to administer drugs effectively. New developments in microneedle technology have led to the creation of dissolvable or degradable microneedles, as well as hollow ones, which allow for higher doses and controlled drug release. Techniques such as iontophoresis, sonophoresis, and electrophoresis can enhance drug delivery when combined with hollow microneedles. Microneedles (MNs) can harm the outer layer of skin, allowing vaccines to pass through, but they are not very effective. On the other hand, iontophoresis can help push vaccines through the skin but struggles with vaccine molecules because of the skin barrier. To solve this, we created a wearable MN patch powered by iontophoresis along with its device to deliver vaccines efficiently through the skin. We used polyacrylamide/chitosan hydrogels that are safe for the body, conduct electricity well, stretch easily, and can hold a lot of vaccine. The method for delivering vaccines with our iontophoresis-driven MN patch involves. “pressing and poking, using iontophoresis for delivery, and triggering an immune response”. Our research showed that combining MN puncturing with iontophoresis greatly improved how well vaccines are delivered through the skin.