1.Demographic survey on women breast cancer patients in a specialty govt.Hospital at Kolkata in India

Nihar Ranjan Pal, Souvik Basak*, Santanu Kumar TripathI, Subrata Chakraborty, Jahar Majumdar

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Abstract

The aim of the present work is to assess extent and quality of the soft skill application by the caregivers of breast cancer women indoor patients of CNCI (Chittaranjan National Cancer Institute) at Kolkata and it was found that 87% of the population was satisfied by availing soft skill application and rest 13% were eager for betterment. To find out the coordination between patients and doctors of CNCI it has been found that 74% of indoor patients were admitted after proper consultation with the doctors and have obtained free bed facility through their advise and recommendations to the higher authority of the hospital. 26% patients were admitted through similar process in the paying bed at lower rate in comparison to the private hospitals. The initiative of CNCI about screening of breast cancer patients in the community has also been evaluated. Improved financial and staff support can uplift the program. By studying percentage of district wise population distribution of Breast cancer patients of West Bengal state admitted at CNCI Kolkata during June 2008 to June 2012, it has been found that Kolkata and adjacent two districts like 24 pgs(N) and 24 pgs(S) are more susceptible to breast cancer having 44% and remaining 56% patients were from other districts. Causes of disease may be unsafe food habit, pollution, socioeconomic parameter, unsafe work schedule etc. The extent and quality of palliative care of this institute has been analyzed and it was found that 90% of the patients availed palliative care.

2.
Human Papilloma Virus infection & spontaneous preterm delivery among pregnant women attending OBG clinic at SMS medical college Jaipur: A case control study

Sonal Agarwal*, Lata Rajoria, B. S. Meena, Mohan Meena

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Abstract

Objective(s): To assess and compare the proportion of Human Papilloma Virus infection in preterm and term delivery.

Method(s): This study was a hospital based case control analytical type of observational study conducted in Dept. of Obs. & Gynae, SMS Medical College, Jaipur from August 2014 to august 2015. All patients coming with labour pains and delivering before 37 weeks gestational age were taken as preterm deliveries (cases)-Group A. All patients coming with labour pains and delivering at or after 37 weeks gestational age were taken as full term deliveries (controls)-Group

B. They were selected according to inclusion criteria. Patients were evaluated after informed consent and detailed history was taken and examination done. After the patient delivered, placental tissue was taken with forceps and saved in normal saline. This sample was sent for HPV PCR-DNA test to microbiology advanced department to detect infection.

Result(s): Both groups were matched according to age, religion, literacy, rural/urban and socioeconomic status characteristics. 2 samples out of 36 samples of group A tested HPV DNA positive with p value <0.001 which is highly significant.

Conclusion(s): HPV is able to infect and replicate in invasive trophoblast cells and that infection by HPV induces pathological sequelae that are associated with placental dysfunction and spontaneous preterm delivery. Perinatal transmission of human papilloma virus may occur directly, during the passage of the fetus through the birth canal and on coming into contact with infected maternal secretions or indirectly, during vaginal delivery from contaminated objects and intrauterine transmission at the time of fertilization from sperm carrying latent virus. HPV PCR technology identifies maternal HPV DNA, thus considerably increasing the sensitivity and specificity to identify HPV.

3.Capping agents influence on structure, optical behaviour and Glucose oxidase mobilization on ZnS QDs: in Glucose sensors viewpoint

Sarita Narkhede and Smita A. Acharya*

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Abstract

In the present attempt, water soluble ZnS QDs were successfully synthesised using different capping agents polyvinalpyrolidone (PVP), mercapto propanic acid (MPA), 2-mercapto ethanol (ME), hydrazine hydrate (HH) and thioglycerol (TG) by co-precipitation route. X-ray diffraction (XRD) study confirms zinc blende structure of all ZnS samples. Transmission Emission microscopy (TEM) images exhibit fine scale spherical particles having size varying in between 7 to 15 nm thus ensure QDs formation. UV-VIS absorption spectra show blue shift in absorption peaks in almost all samples; however for ME-ZnS the shift is largest and PVP-ZnS it is smallest.

Capping agents induced blue shift in absorption peak attribute to variation in size of QDs. Ligands existence with ZnS QDs are also confirmed by Fourier Transform Infrared spectroscopy (FTIR). A typical room temperature photoluminescence (PL) spectrum of ZnS QDs shows that the spectrum is dominated by characteristics deep level emission peak in between 500 and 550 nm, correlated with transition from conduction band to sulphur vacancies defect structure, which acts as doubly ionized donor centres. The PL spectra of capped-ZnS QDs bioconjugated by glucose oxidase (GOx) enzymes are effectively quenched with glucose content. The kinetics of the enzymatic-catalyzed reaction are estimated by Michaelis-Menton kinetic parameters (K and Vmax). The values of Km and V exhibit that PVP as capping agents are more supportive for GOx mobilization on ZnS and respective enzymatic activity.

4.Quorum sensing inhibition - combating biofilm infections - A target to remedy

Kranti K.* and Apoorva Kumar

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Abstract

Periodontal disease is an inflammatory disease causing destruction of the supporting structures of the teeth. Micro-organisms can actively maintain their three-dimensional biofilm structure and lead to its progression. The severity of periodontal infection can be greatly affected by the ensuing host response. Increased synthesis of the signal molecules known as autoinducers by the pathogenic bacteria integrate with native signal-transduction systems to produce regulatory networks that coordinate gene expression and function as a decision-making process to regulate the production of virulence factors. Any mechanism that can effectively interfere with this bacterial cross-talk, could be used for quorum sensing inhibition and preventing microbial infections. Pharmacologic interference of intercellular signaling includes furanones, herbal products such as garlic, curcumin, citrus flavonoids, turmeric or L-canavanine. Use of such plant based molecules along with antibiotics may cause some benefit in combating the periodontal disease. The use of sophisticated drugs comprising both biofilm-controlling compounds and antibiotics can be used to treat periodontal infections.

5.Comparative efficiency of various Mathematical functions on unadjusted lactation curve in Jaffrabadi Buffalo

B. D. Savaliya* and S. S. Parikh

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Abstract

A study was carried out on 310 normal lactations (1-6 parity) pertaining to 123 Jaffrabadi buffaloes spread over 15years (1978-1992) maintained at Cattle Breeding Farm, Junagadh Agricultural University, Junagadh (Gujarat). Four lactation curve models viz. Exponential, Parabolic exponential, Inverse polynomial and Gamma-type functions were fitted on weekly milk yields and their relative efficiency was compared. Gamma-type function described the best fit with highest coefficient of determination (99.82%) whereas, least coefficient of determination (85.25%) was observed in Exponential function. Exponential function could not explain initial and peak phase of the lactation, however, it explains only the descending segment of the lactation curve. The trend of Inverse polynomial function, however, indicated that the function might be most suited to buffaloes which start their lactation at very low level of production, reach their peak very early and then start declining at an early stage. Gamma-type and Inverse polynomial functions should be preferred over others for predicting milk yield at any stage of lactation in Jaffrabadi buffalo. Gamma-type function is recommended for lactation data of Jaffrabadi buffalo to achieve efficient breeding and feeding management of dairy herds.

6.Amorphous silica nanoparticles show concentration and time-dependent toxicity on Human HaCaT Cells

Abdulmajeed G. Almutary*, Amanda Ellis, Barbara J.S. Sanderson

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Abstract

Background: The wide use of nanomaterials in medicine and biology and the unknown cytotoxicity of some nanoparticles heighten the demand for health and safety guidelines. The creation of these guidelines relies on experimental investigation to inform guidelines to eliminate the risk of exposure from newly synthesized nanoparticles. Skin contact of nanoparticles can cause skin cancer; therefore, the focus of this study was to identify the cytotoxicity of these particles to skin cells in an in vitro model.

Methods: The toxicity of 12-nm amorphous silica (SiO nanoparticles following 4, 24 and 48h exposure was investigated using a human keratinocyte cell line (HaCaT) with [3-(4,5dimethylthiazol-2yl)-diphenyltetrazolium bromide] (MTT) and crystal violet assays. Eleven concentrationsof 12-nm SiO2 ranging between 0.05-10 mg/mL were tested.

Results: At 4, 24 and 48h exposure, a dose dependent increase in cell killing with increasing concentration were observed when screened with the MTT assay. At 24h for concentrations ≥ 2 mg/mL, relative survival decreased when assayed by the MTT assay and relative cell number decreased when assayed with the crystal violet assay. After 48htreatment, cytotoxicity was observed at every treatment concentration assessed with the MTT and crystal violet assays. The level of cytotoxicity was also time dependent (4, 24, 48h)at every concentration. The level of cytotoxicity after 48h treatment was equal to or less than that of cell population streated for 24h.

Conclusion: Silica nanoparticles are toxic to cultured human skin cells at a concentration as low as 0.05 mg/mL for 48h treatment when screen by the crystal violet assay. When nanoparticles of consistent structure and surface area are used to treat human cells in culture, results varied between two well recognised colourimetric bioassays. However, with both assays, silica nanoparticles are toxic to human skin cells in vitro and toxicity is both concentration dependent and time dependent.

7.NTRU cryptosystem with Jordan canonical form

Khushboo Thakur*, B.P. Tripathi

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Abstract

The NTRU encryption scheme is an appealing another to well-known encryption schemes such as RSA, ElGamal, and ECIES. The security of NTRU relies on the hardness of computing short lattice vectors and thus is a capable candidate for being quantum computer resistant. There has been extensive research on efficient implementation of the NTRU encryption scheme. In this paper, we proposed new cryptosystem which is improvement of Nanda and Nayak scheme, which is based on Jordan canonical form replacing Gaussian Integer Matrix. New scheme is more efficient and low time consuming.

8.Is personality of schizophrenics & bipolar patients are similar?

Rupali Chandola

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Abstract

Background: Although serious mental illness is associated with increased risk of violent behavior. Personality of an individual determines his behavior towards others. Most of the evidence available pertains to schizophrenia and bipolar disorder. Schizophrenic and bipolar patients behave differently. Therefore, study was conducted to know that, which personality dimension of schizophrenic and bipolar is to be similar or differ.

Methods: Study examined personality dimension of 80 subjects selected purposively. The study was conducted on 40 indoor schizophrenics (20 male & 20 female) and bipolar (20 male & 20 female) patients they were admitted in Noormanzil Psychiatric Clinic & Hospital, Lucknow, U.P. India. Age ranging between 20-50 years served as participants. Dimension Personality Inventory (DPI) was administered on all the included subjects.

Result: Personality of schizophrenic can be differentiated from bipolar patient‘s enthusiastic-non enthusiastic, suspicious- trusting and emotional instable-emotional stable dimension of DPI.

Conclusion: Bipolar female participants found to be more submissive.

9.Vehicle speed monitoring system for safe riding and minimizing accident in prone area

S. Vishnu

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Abstract

People lost their valuable life by making known mistake while driving in hilly area, highways and speed limiting areas. Now a day’s peoples are driving very fast so accident are occurring frequently. Currently the survey observes 1, 37,000 people dies in India every year and in that 1 dies every 4 minutes. The main reason for an accident by the national crime roads bureau, law commission of India says that only by over speeding in accident prone areas and violating the road rules. So in order to avoid such kind of accidents and to alert the driver about the speed limits in such kind of places the highway department has already placed the signboards. But sometimes it may not be possible to view the signboards and leads to disastrous road accidents. So here our project contribution is more useful. Here we are making the driver to alert while exceeding the speed limit in that particular area, if they are supposed to relegate the alert given by the alarm, the respective driver has to pay the penalty or else the case will be booked automatically. Our system also generates the penalty receipt and sent to the respective candidate and it can be done by using CDMA technology. The existing technology still does not reduce the number of accidents. Hence there is a need to implement intelligent speed adoption (ISA) in vehicles. We propose automatic speed control based on RF signal for accident prone area, hospital, and school roads, where the speed control within the limit is required. The methodology explains that, various transmitters are placed in those above said zones and the receiver fitted in the vehicle will sense the speed and it can be successfully done.

10.Association of Red Cell Distribution Width with the presence and severity of Preeclampsia

Haritha Mannem*, Lata Rajoria, Mohan Meena, B. S. Meena

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Abstract

Objective(s): To investigate the correlation of red cell distribution width with preeclampsia and its severity.

Method(s): This study was a hospital based observational descriptive comparative analysis type done at Department of Obstetrics and gynecology, SMS medical college, Jaipur. Study participants included singleton third trimester pregnant women admitted in Department of obstetrics and gynecology, SMS medical college, Jaipur after applying selection criteria. 25 severe preeclampsia cases were included on first cum first basis after beginning the study. Normotensive and mild preeclampsia cases just next to each severe preeclampsia case were also included in the study for comparative group. All participants underwent blood collection via antecubital vein puncture. Red cell distribution width was measured using automated hematology analyzer.

Result(s): The mean RDW-SD and RDW-CV values of severe preeclampsia group were significantly higher compared to mild preeclampsia and normotensive group.(p<0.0001) It was also observed that the mean values of RDW-SD were more significantly associated with the severity of preeclampsia than the mean values of RDW-CV.

Conclusion(s): We conclude from our study that inflammatory process has a significant role in pathophysiology of preeclampsia. The severity of inflammation is depicted by the increase in RDW values in preeclampsia. In our study RDW values are definitely raised among the preeclampsia groups compared to the controls which signify their role in contributing to the early diagnosis of the condition. RDW values are also associated with the severity of the condition which is further helpful in the management of these high risk patients. We further observed that RDW-SD values are more closely associated than RDW-CV values to the severity of the disease. Our study concludes that simple determination of RDW values help in both diagnosing and assessing the severity of preeclampsia.

11.Biochemical studies on the toxic effects of Metanil Yellow on Teleostean catfish Heteropneustes fossilis (Bloch)

Rituparna Sarkar* and Apurba Ratan Ghosh

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Abstract

The experiment was conducted on fresh water teleost fish Heteropneustes fossilis (Bloch). The chronic toxicity for an exposure of 30 and 45 days with a sub-lethal dose of 2.0 g/l was studied on H. fossilis. Different biochemical investigations like protein content, amylase, protease and lipase activity were carried out on different tissues like oesophagus, stomach, intestine (anterior, middle and posterior), liver, pancreas and muscle of control and Metanil Yellow treated H. fossilis. The present study showed the significant changes in protein content and also in amylase, protease and lipase activity of H. fossilis due to the toxicosis of Metanil Yellow.

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May,2016

1.Demographic survey on women breast cancer patients in a specialty govt.Hospital at Kolkata in India

2.
Human Papilloma Virus infection & spontaneous preterm delivery among pregnant women attending OBG clinic at SMS medical college Jaipur: A case control study

3.Capping agents influence on structure, optical behaviour and Glucose oxidase mobilization on ZnS QDs: in Glucose sensors viewpoint

4.Quorum sensing inhibition - combating biofilm infections - A target to remedy

5.Comparative efficiency of various Mathematical functions on unadjusted lactation curve in Jaffrabadi Buffalo

6.Amorphous silica nanoparticles show concentration and time-dependent toxicity on Human HaCaT Cells

7.NTRU cryptosystem with Jordan canonical form

8.Is personality of schizophrenics & bipolar patients are similar?

9.Vehicle speed monitoring system for safe riding and minimizing accident in prone area

10.Association of Red Cell Distribution Width with the presence and severity of Preeclampsia

11.Biochemical studies on the toxic effects of Metanil Yellow on Teleostean catfish Heteropneustes fossilis (Bloch)

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