Abstract
Introduction: Respiratory distress syndrome (RDS) is one of the most common causes of mortality and morbidity in preterm neonates. Surfactant and CPAP and mechanical ventilation have been the main stay management techniques in RDS. Surfactant is a costly intervention and most patients are transported and reach the treatment facility at a later time. This study aims at comparing the effects of CPAP alone to CPAP with surfactant.
Methods: The study was a randomized control clinical trial with 160 neonates born at Niloufer childrens hospital. Neonates born between 28 0/7 to 34 6/7 with evidence of RDS were randomized to receive either cpap alone or cpap with surfactant. Both the groups were compared fpr primary and secondary outcomes. The primary outcome measured was treatment success defined by the criteria. Secondary outcomes are mortality and other complications.
Results: During the study period of 12 months, 160 neonates were included in the study. The mean gestational age was 30.6 weeks. Cpap was started at a mean age of 35 minutes and surfactant was started at a mean age of 2.1 hours.
The rates of treatment success did not vary significantly in between the two groups(p=0.7). the rates of mortality did not differ between the groups (p=0.4).
The rates of secondary outcomes differed in terms of incidence of BPD, duration of hospital stay and duration of oxygen requirement. The incidence of BPD was more with surfactant group( p=0.15). The mean duration of hospital stay was longer in cpap group(p=0.00), the mean duration of oxygen requirement was longer with cpap group (p=0.00). In case of treatment failure, the average duration of mechanical ventilation was 3.3 days in CPAP group and 4.83 days in INSURE group. P=0.046.
Conclusions: CPAP is an effective alternative treatment to surfactant in selected neonates.
CPAP is a cost effective, less invasive, and requires less skill than surfactant for treatment of RDS. It is an ideal management option for RDS in a developing country.