Abstract
Oral submucous fibrosis (OSMF) is having highest malignant potential than any other oral premalignant lesions. OSMF now accepted globally as an Indian disease, the understanding of the exact role of alkaloids and other etiological agents with respect to pathogenesis will help the management and minimize the blind clinical trials and treatment modalities. There are few clinical trials where Aloe vera is been used in the treatment of oral diseases such as oral lichen planus, recurrent aphthous stomatitis, oral pemphigus, herpetic stomatitis, radiation induced mucositis. Aloe vera has been used in many systemic diseases because of its multiple therapeutic properties such as antioxidant, anti-helminthic, anti-inflammatory, anti-viral, lipolytic, laxative, anti- arthritic and also as a uterine stimulant. The present article aims in evaluation of these clinical trials to assess the efficacy of Aloe vera as a therapeutic modalities in OSMF.